Dr. Michael J. Paidas

Jackson Health Services

 Dr. Michael J. Paidas is Professor and Chair, Department of Obstetrics and Gynecology, Miller School of Medicine, Chief of Service, Jackson Memorial Hospital, Jackson Health System, and Chief of Service, University Health Tower, University of Miami.  Dr. Paidas joined the Jackson Health System and the U Miami Miller School of Medicine following a sixteen year tenure at Yale School of Medicine where he was Professor and Vice Chair, Obstetrics, Gynecology, & Reproductive Sciences. He also was Director of the Maternal Fetal Medicine Fellowship, and Director of the Yale Women and Children’s Center for Blood Disorders & Preeclampsia Advancement, and Co-Director of the National Hemophilia Foundation-Baxter Clinical Fellowship at Yale. He has served as Interim Director, Section of Maternal Fetal Medicine, and Interim Section Chief, Maternal Fetal Medicine of Yale New Haven Hospital. 


 

EDUCATION AND TRAINING

A recipient of the Headmaster’s Scholarship, Dr. Paidas received his undergraduate degree from Fairfield University, cum laude.   Subsequently, Dr. Paidas graduated from Tufts University School of Medicine.   He completed his internship and residency in Obstetrics and Gynecology at Pennsylvania Hospital, Philadelphia, PA and a fellowship in Maternal Fetal Medicine at The Mount Sinai School of Medicine, New York, NY. After working at Tufts University School of Medicine and New York University, Dr. Paidas joined the Yale faculty in 2002, and he remains as Adjunct Professor, in the Department of Obstetrics, Gynecology and Reproductive Sciences.


CLINICAL AND RESEARCH INTERESTS

Dr. Paidas’ career in medicine has focused generally in the fields of reproduction, perinatal medicine and hemostasis, with activities spanning patient care, translational research and clinical trials.   

Dr. Paidas is recognized as international authority in hemostasis disorders and women’s health.  He has authored or co-authored 126 peer reviewed articles and his work is published in a variety of scientific and clinical journals including PNAS, Pharmacology & Therapeutics, Cell Death and Differentiation/Nature, and The Lancet.  He has authored one book and 35 book chapters, 155 abstracts, and has given 300 presentations or courses. His research is supported by federal and non-federal agencies, including the NIH. 


For 18 years, Dr. Paidas has assumed a leading role in research concerning the diagnostic and therapeutic applications in civilian and military settings of PreImplantation Factor (PIF), which possesses key immune modulatory, neuroprotective & neuroregenerative properties in pregnancy and non-pregnancy related conditions. PIF has recently been administered in humans, having received FDA Fast Track and Orphan Drug Designation for autoimmune hepatitis and graft versus host disease.  Dr. Paidas is Principal Investigator of an NIH grant, evaluating PIF as a treatment for radiation injury from the National Institute of Allergy & Infectious Disease. 

Some of his other notable contributions have included the following: identification of the unique hemorrhagic risks associated with fetal blood sampling in the setting of alloimmune thrombocytopenia; description of the regulatory factors of the Protein C system in pregnancy; clinical use of recombinant antithrombin replacement in deficiency states; and elucidation of the subsequent health consequences of hypertensive disorders and preterm delivery. He is the principal investigator of PRESERVE-1, a multicenter, randomized, double blind, placebo controlled trial, designed to determine whether maternal administration of recombinant antithrombin improves fetal, neonatal and maternal outcomes in early onset preeclampsia.  With his support and mentoring, Dr. Paidas’ team has recently described a novel application of a non-teratogenic mood stabilizing drug that is effective in treating perinatal cytomegalovirus in preclinical models. Dr. Paidas is the Principal Investigator for an upcoming clinical trial evaluating the benefit of fibrinogen replacement in the setting of postpartum hemorrhage associated with placenta accreta.


SELECTED HONORS

Dr. Paidas is the recipient of The David J. Leffell, MD Prize for Clinical Excellence at Yale in 2010, given annually to one faculty member, and Tufts Medical Alumni Association, Dean’s Award. He received a Master of Arts Honorary Degree from Yale University in 2013.   Dr. Paidas is included in the top 1% physician by specialty in the nation according to the US News and World Report. Dr. Paidas serves on the Medical Advisory Board of the National Hemophilia Foundation, Medical Advisory Board of the Preeclampsia Foundation, and the Advisory Board of Nursing and Health Studies of Fairfield University.  Dr. Paidas was Co-Chair of the Thrombosis and Hemostasis Societies of North America 2016 and 2018 Biennial Summits.  Dr. Paidas has served on several federal panels, including the NIH and FDA, and is a contributing author of The National Partnership for Maternal Safety.  

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